Posted under Fertility Treatment by Dr. Rajeev Agarwal

Tags:


Letrozole Is Safe

I am writing this article because Letrozole is a very commonly used drug by Infertility Specialists the world over, but unfortunately it has also attracted a lot of controversy and negative publicity. Would like to clear the air on some of the issues involved.

Ovulatory dysfunction is one of the most common causes of reproductive failure in sub fertile and infertile couples. Since the first clinical trial was published in 1961, Clomiphene Citrate (CC) has been the front-line therapy for ovulation induction. Its use quickly expanded to other empiric indications, such as luteal phase defect and the enhancement of fecundity in unexplained infertility. While CC is able to make eggs in 80% of patients, only half that number, or 40% will conceive. This is because CC has certain negative effects on the lining of the womb which hamper the implantation of the fertilized embryo. Failure to respond to CC occurs in up to 20% of cases, which may then require the use of injectable gonadotropins. Clearly, an inexpensive yet equally efficacious oral alternative would be ideal.

Recent research has focused on the successful use of aromatase inhibitors, mainly letrozole, for ovulation induction. We have been incorporating letrozole into treatment plans for appropriately selected patients for quite some time now. In India it is sold as Letroz, Letoval etc. Letrozole is a drug which has conventionally been used for Breast cancer treatment. This is only because Breast cancer requires the female hormone Estrogen for its sustenance and Letrozole is an anti oestrogen drug. It is because of this property that Letrozole can also be used to make eggs grow as in the absence of Estrogen, the hormones FSH and LH start to increase and stimulate the ovaries to make eggs bigger. Letrozole is commonly used in a dosage of 2.5mg twice daily from Day 2 to day 6. Several research papers have even used single day dosage of 20mg with good results. Single doses as high as 60mg have been administered without negative results.

Letrozole has several advantages:
1. Letrozole has a very short half-life (~45 hours) and, therefore, is quickly cleared from the body. For this reason, it is less likely to adversely affect the endometrium and cervical mucus.
2. The results of several studies show that Letrozole and Letrozole + FSH cycles had the highest pregnancy rates.

There has been a lot of controversy that Letrozole use causes deformed babies, or that Indians have been made Guinea pigs for its trials. On the contrary, Letrozole is cleared faster from the blood than CC and therefore has lesser chances of affecting the conception, when it happens. CC in known to stay in the blood for upto six months after intake. Much before Letrozole came to India, hundreds of research papers were written all over the world and every paper only found benefits in its use. And lastly, before I rest my case, after all that media hype, Letrozole has been quietly given FDA approval by the government, for use in Fertility. Here is a link to a relevant artcile published in a reputed Journal, Fertility and Sterility in 2006: dx.doi.org/10.1016/j.fertnstert.2006.03.014

So, it is better you consult with a gynecologist and infertility specialist Dr. Rajeev Agarwal (director of Care IVF) before you are going under medications. It is better you understand the good and bad things of a controversial subject before you are going through a course.

There are number of infertility clinics. Study and check the infertility clinics in Kolkata before you enroll yourself for your IVF success.

 



Leave a Comment

Related Posts


How do Polycystic Ovaries Affect Pregnancy
Pregnancy is a wonderful aspect of a woman’s life. Nurturing a life in your womb is one of the best ...
Read More
Brief Summary of the Indian Laws on ART and Surrogacy
What do Shah Rukh Khan, Karan Johar, and Tusshar Kapoor have in common? Well, they are all A-listed ...
Read More
5 Things You Should Know About Fertility
If you are reading this article then chances are high that you are trying or planning to have childr ...
Read More
What You Can Do to Improve Your Egg Quality
Your quality of egg determines whether you can conceive or not. Once you are in your 30s, the quali ...
Read More
5 Tips for Successful Surrogacy
Being pregnant is one of the most wonderful feeling for any woman. However, things are a bit differe ...
Read More
Secondary Infertility - 8 Facts to Know
Secondary fertility is when a woman cannot get pregnant or isn’t capable of carrying a pregnancy to ...
Read More
5 Common Myths About IVF Treatment
Despite the growing popularity of in-vitro fertilization (IVF) as an effective solution for infertil ...
Read More
Corrective Surgeries That Are Performed Before IVF
You may face unexplained fertility issues or have experienced failed IVF cycle. In such cases, often ...
Read More
Trying to Conceive - When is Sperm Aspiration Recommended
Infertility due to male factor is not an uncommon issue. There are several factors that determine th ...
Read More
Ovarian Drilling
Women with PCOS (Poly Cystic Ovarian Syndromes) have irregular menstrual periods and do not ovulate ...
Read More
Why IVF Fails
IVF or in-vitro fertilization is a process in which both egg and sperm are collected from the indivi ...
Read More
Role of Hysteroscopy in IVF
What is Hysteroscopy, why is it so important ? Should we doing Hysteroscopy ...
Read More
Sperm Banking
Information about Sperm Banking, both for Donors and also for those who wil ...
Read More
Life Begins at 40 with the Success of IVF
Most women around the age of 30, whom I have seen do show apprehension regarding that particular age ...
Read More
Tubal Patency Testing Under Best IVF Clinic in Kolkata
Fallopian tubes arise from the womb (uterus) and curve around the ovaries on either side. The ends o ...
Read More

Useful Videos


© 2017 Care Fertility Solutions Pvt Ltd.. All Rights Reserved.

Design By: AV Solutions